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Improvement of plasma adiponectin, leptin and C‐reactive protein concentrations by orlistat: a systematic review and meta‐analysis
Author(s) -
Derosa Giuseppe,
Maffioli Pamela,
Sahebkar Amirhossein
Publication year - 2016
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/bcp.12874
Subject(s) - adiponectin , meta analysis , adipokine , orlistat , medicine , leptin , confidence interval , body mass index , confounding , c reactive protein , endocrinology , obesity , gastroenterology , weight loss , insulin resistance , inflammation
Aims To conduct a systematic review and meta‐analysis of relevant randomized clinical trials (RCTs) to ascertain the effect size of orlistat in modulating plasma levels of adipokines, ghrelin and C‐reactive protein (CRP). Methods Medline, SCOPUS, Web of Science and Google Scholar databases were searched. A random‐effects model and the generic inverse variance method were used for quantitative data synthesis. Heterogeneity was quantitatively assessed using I 2 index. Sensitivity analyses were conducted using the one‐study remove approach. Random‐effects meta‐regression was performed using unrestricted maximum likelihood method to evaluate the impact of duration of treatment, percentage change in body mass index (BMI) and baseline BMI values as potential confounders of the estimated effect size. Results Meta‐analysis suggested a significant increase in plasma levels of adiponectin [weighted mean difference (WMD): 19.18%, 95% confidence interval (CI): 5.80, 32.57, p = 0.005] and significant reductions in plasma levels of leptin (WMD: −13.24%, 95% CI: −20.69, −5.78, p = 0.001) and CRP (WMD: −11.52%, 95% CI: −16.55, −6.49, p < 0.001) following treatment with orlistat. In meta‐regression, changes in plasma concentrations of adiponectin, leptin and CRP were associated with duration of treatment, but not with either change in BMI or baseline BMI values. Conclusion Orlistat is effective in increasing plasma concentrations of adiponectin and decreasing those of leptin and CRP.