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Is the era of intravenous proton pump inhibitors coming to an end in patients with bleeding peptic ulcers? Meta‐analysis of the published literature
Author(s) -
Jian Zhixiang,
Li Hui,
Race Nicholas S.,
Ma Tingting,
Jin Haosheng,
Yin Zi
Publication year - 2016
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/bcp.12866
Subject(s) - medicine , peptic , meta analysis , confidence interval , randomized controlled trial , relative risk , gastroenterology , proton pump inhibitor , peptic ulcer
Aims Oral and intravenous proton pump inhibitors (PPIs) are equipotent in raising gastric pH. However, it is not known whether oral PPIs can replace intravenous PPIs in patients with bleeding peptic ulcers. Methods We conducted a systematic review and meta‐analysis of randomized controlled trials to compare oral and intravenous PPIs among patients with peptic ulcer bleeding. A search of all major databases and relevant journals from inception to April 2015, without a restriction on languages, was performed. Results A total of 859 patients from seven randomized controlled trials were included in the meta‐analysis. Similar pooled outcome measures were demonstrated between the two groups in terms of oral PPIs vs . intravenous PPIs in the rate of recurrent bleeding within the 30‐day follow‐up period [risk ratio = 0.90; 95% confidence interval (CI): 0.58, 1.39; P = 0.62; I 2 = 0%). In terms of the rate of mortality, both oral and intravenous PPIs showed similar outcomes, and the pooled risk ratio was 0.88 (95% CI: 0.29, 2.71; P = 0.82; I 2 = 0%). Likewise, no significant difference was detected in the need for blood transfusion and length of hospital stay; the pooled mean differences were −0.14 (95% CI: –0.39, 0.12; P = 0.29; I 2 = 32%) and −0.60 (95% CI: –1.42, 0.23; P = 0.16; I 2 = 79%), respectively. Conclusions Our results suggest that oral PPIs are a feasible, safe alternative to intravenous PPIs in patients with bleeding peptic ulcers, and may be able to replace intravenous PPIs as the treatment of choice in these patients.