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Repurposing some older drugs that cross the blood–brain barrier and have potential anticancer activity to provide new treatment options for glioblastoma
Author(s) -
RundleThiele Dayle,
Head Richard,
Cosgrove Leah,
Martin Jennifer H.
Publication year - 2016
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/bcp.12785
Subject(s) - glioblastoma , medicine , repurposing , drug repositioning , oncology , brain tumor , blood–brain barrier , temozolomide , pharmacology , overall survival , brain cancer , drug , cancer , cancer research , pathology , central nervous system , biology , ecology
Glioblastoma is a brain neoplasm with limited 5‐year survival rates. Developments of new treatment regimens that improve patient survival in patients with glioblastoma are needed. It is likely that a number of existing drugs used in other conditions have potential anticancer effects that offer significant survival benefit to glioblastoma patients. Identification of such drugs could provide a novel treatment paradigm.