Repurposing some older drugs that cross the blood–brain barrier and have potential anticancer activity to provide new treatment options for glioblastoma | Zendy

RundleThiele Dayle | Zendy; Head Richard | Zendy; Cosgrove Leah | Zendy; Martin Jennifer H. | Zendy

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Repurposing some older drugs that cross the blood–brain barrier and have potential anticancer activity to provide new treatment options for glioblastoma

Author(s) -

RundleThiele Dayle,

Head Richard,

Cosgrove Leah,

Martin Jennifer H.

Publication year - 2016

Publication title -

british journal of clinical pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.216

H-Index - 146

eISSN - 1365-2125

pISSN - 0306-5251

DOI - 10.1111/bcp.12785

Subject(s) - glioblastoma , repurposing , medicine , brain tumor , oncology , blood–brain barrier , overall survival , drug repositioning , brain cancer , pharmacology , drug , cancer research , cancer , pathology , central nervous system , biology , ecology

Glioblastoma is a brain neoplasm with limited 5‐year survival rates. Developments of new treatment regimens that improve patient survival in patients with glioblastoma are needed. It is likely that a number of existing drugs used in other conditions have potential anticancer effects that offer significant survival benefit to glioblastoma patients. Identification of such drugs could provide a novel treatment paradigm.

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