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The role of epoxyeicosatrienoic acids in the cardiovascular system
Author(s) -
Yang L.,
MäkiPetäjä K.,
Cheriyan J.,
McEniery C.,
Wilkinson I. B.
Publication year - 2015
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/bcp.12603
Subject(s) - vascular tone , medicine , epoxyeicosatrienoic acid , endothelium , pharmacology , tone (literature) , bioinformatics , neuroscience , cardiology , vasodilation , biology , metabolism , cytochrome p450 , art , literature
There is increasing evidence suggesting that epoxyeicosatrienoic acids (EETs) play an important role in cardioprotective mechanisms. These include regulating vascular tone, modulating inflammatory responses, improving cardiomyocyte function and reducing ischaemic damage, resulting in attenuation of animal models of cardiovascular risk factors. This review discusses the current knowledge on the role of EETs in endothelium‐dependent control of vascular tone in the healthy and in subjects with cardiovascular risk factors, and considers the pharmacological potential of targeting this pathway.