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An individual patient data meta‐analysis on factors associated with adverse drug events in surgical and non‐surgical inpatients
Author(s) -
Boeker Eveline B.,
Ram Kim,
Klopotowska Joanna E.,
Boer Monica,
Creus Montse Tuset,
Andrés Ana L.,
Sakuma Mio,
Morimoto Takeshi,
Boermeester Marja A.,
Dijkgraaf Marcel G. W.
Publication year - 2015
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/bcp.12504
Subject(s) - medicine , polypharmacy , odds ratio , adverse effect , incidence (geometry) , emergency medicine , logistic regression , psychological intervention , poisson regression , intensive care medicine , population , physics , environmental health , optics , psychiatry
Aim The incidence of adverse drug events ( ADEs ) in surgical and non‐surgical patients may differ. This individual patient data meta‐analysis ( IPDMA ) identifies patient characteristics and types of medication most associated with patients experiencing ADEs and suggests target areas for reducing harm and implementing focused interventions. Methods Authors of eligible studies on preventable ADEs ( pADEs ) were approached for collaboration. For assessment of differences among (non‐)surgical patients and identification of associated factors descriptive statistics, P earson chi‐square, Poisson and logistic regression analyses were performed. For identification of high risk drugs ( HRDs ), a model was developed based on frequency, severity and preventability of medication related to ADEs . Results Included were 5367 patients from four studies. Patients aged ≥ 77 years experienced more ADEs and pADEs compared with patients aged ≤ 52 years (odds ratios ( OR ) 2.12 (95% CI 1.70, 2.65) and 2.55 (95% CI 1.70, 3.84), respectively, both P < 0.05). Polypharmacy on admission also increased the risk of ADEs ( OR 1.21 (95% CI 1.03, 1.44), P < 0.05) and pADEs ( OR 1.85 (95% CI 1.34, 2.56), P < 0.05). pADEs were associated with more severe harm than non‐preventable ADEs (54% vs . 32%, P < 0.05). The top five HRDs were antibiotics, sedatives, anticoagulants, diuretics and antihypertensives. Events associated with HRDs included diarrhoea or constipation, abnormal liver function test and central nervous system events. Most pADEs resulted from prescribing errors (90%). Conclusion Elderly patients with polypharmacy on admission and receiving antibiotics, sedatives, anticoagulants, diuretics or antihypertensives were more prone to experiencing ADEs . Efficiency in prevention of ADEs may be improved by targeted vigilance systems for alertness of physicians and pharmacists.