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The evolution of three decades of antiretroviral therapy: challenges, triumphs and the promise of the future
Author(s) -
Tseng Alice,
Seet Jason,
Phillips Elizabeth J.
Publication year - 2015
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/bcp.12403
Subject(s) - pharmacogenomics , human immunodeficiency virus (hiv) , drug , medicine , intensive care medicine , antiretroviral therapy , pharmacology , immunology , viral load
The evolution of human immunodeficiency virus ( HIV ) treatment has improved our understanding and management of complex pharmacological issues that have driven improved outcomes and quality of life of the HIV ‐infected patient. These issues include adherence, long‐ and short‐term toxicities, pharmacoenhancement, pharmacogenomics, therapeutic drug monitoring, differential penetration of drugs into sanctuary sites, such as the central nervous system, genital tract and small bowel, and drug–drug and drug–food interactions related to cytochrome P 450 drug‐metabolizing enzymes, uridine diphosphate glucuronyltransferases and drug transporters, to name a few. There is future promise, as an increased understanding of the immunopathogenesis of HIV and global public health initiatives are driving novel treatment approaches with goals to prevent, control and, ultimately, eradicate HIV .