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Targeting virulence not viability in the search for future antibacterials
Author(s) -
Heras Begoña,
Scanlon Martin J.,
Martin Jennifer L.
Publication year - 2015
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/bcp.12356
Subject(s) - virulence , antibiotics , microbiology and biotechnology , antibiotic resistance , bacteria , biology , gene , genetics
New antibacterials need new approaches to overcome the problem of rapid antibiotic resistance. Here we review the development of potential new antibacterial drugs that do not kill bacteria or inhibit their growth, but combat disease instead by targeting bacterial virulence.