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Pharmacogenomics – how close/far are we to practising individualized medicine for children?
Author(s) -
Sing ChorWing,
Cheung ChingLung,
Wong Ian C. K.
Publication year - 2015
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/bcp.12338
Subject(s) - pharmacogenomics , international hapmap project , medicine , personalized medicine , precision medicine , drug development , clinical practice , alternative medicine , bioinformatics , drug , intensive care medicine , pharmacology , genome , human genome , biology , family medicine , pathology , genetics , gene
The translation of pharmacogenomics into clinical practice is a key approach for practising individualized medicine, which aims to maximize drug efficacy and minimize drug toxicity. Since the completion of both the H uman G enome P roject and the I nternational H ap M ap project, the development of pharmacogenomics has been greatly facilitated. However, progress in translating pharmacogenomics into clinical practice, especially in paediatric medicine, is unexpectedly slow. Many challenges from different areas remain. This paper discusses the existing applications and the limitations to the implementation of paediatric pharmacogenomics, as well as possible solutions for overcoming these limitations and challenges.