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Association between nonsteroidal anti‐inflammatory drug use and brain tumour risk: a meta‐analysis
Author(s) -
Liu Yanqiong,
Lu Yu,
Wang Jian,
Xie Li,
Li Taijie,
He Yu,
Peng Qiliu,
Qin Xue,
Li Shan
Publication year - 2014
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/bcp.12311
Subject(s) - aspirin , medicine , relative risk , meta analysis , confidence interval , cohort study , subgroup analysis , epidemiology , cohort , drug , randomized controlled trial , oncology , pharmacology
Aims Several epidemiological studies have evaluated the association between nonsteroidal anti‐inflammatory drugs ( NSAID s) and brain tumour risk. However, results from these studies have been inconsistent. The aim of this detailed meta‐analysis is to review and summarize the evidence on this association. Methods A comprehensive search for articles published up to S eptember 2013 was performed. Studies evaluating the association between exposure to NSAID s and risk of brain tumours were included. Random‐effects meta‐analytical models were used to calculate the relative risk ( RR ) and corresponding 95% confidence intervals ( CI s). Sensitivity analyses, G albraith plots and subgroup analyses were also performed. Results Ten studies (six case–control studies, three cohort studies and one randomized controlled trial), published between 2003 and 2013, were included in this analysis. Compared with non‐use, overall use of NSAID s was not statistically significantly associated with brain tumour risk based on the random‐effects models ( RR = 1.01; 95% CI = 0.89, 1.15). No differences were observed when analyses were stratified by gender and brain tumour subtype. Specific analysis for aspirin and non‐aspirin NSAID s yielded similar results. However, a slightly increased risk of brain tumour in NSAID users was observed in cohort studies ( RR = 1.32; 95% CI = 1.06, 1.64; P = 0.014). Furthermore, our analysis did not show a significant association between frequency and dose of aspirin use and brain tumour risk. Conclusions Use of NSAID s (aspirin and non‐aspirin NSAID s) does not appear to be associated with brain tumour risk, but larger studies are needed to substantiate this relationship.