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A systematic review of hospitalization resulting from medicine‐related problems in adult patients
Author(s) -
Al Hamid Abdullah,
Ghaleb Maisoon,
Aljadhey Hisham,
Aslanpour Zoe
Publication year - 2014
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/bcp.12293
Subject(s) - interquartile range , polypharmacy , medicine , adverse effect , drug , emergency medicine , diabetes mellitus , retrospective cohort study , drug reaction , intensive care medicine , pharmacology , endocrinology
Aims Medicine‐related problems ( MRP s) represent a major issue leading to hospitalization, especially in adult and elderly patients. The aims of this review are to investigate the prevalence, causes and major risk factors for MRP s leading to hospitalization in adult patients and to identify the main medicine classes involved. Methods Studies were identified through electronic searches of M edline, E mbase, S copus and I nternational P harmaceutical A bstracts between J anuary 2000 and M ay 2013. A systematic review was conducted of both retrospective and prospective studies. Studies included were those involving hospitalization resulting from MRP s in adults (≥18 years old), whereas studies excluded were those investigating drug misuse and abuse and studies investigating MRPs in hospitalized patients. Data analysis was performed using SPSS version 20. Results Forty‐five studies were identified, including 21 that investigated hospitalization resulting from adverse drug reactions, six studies that investigated hospitalization due to adverse drug events and 18 studies that investigated hospitalization due to MRP s. The median prevalence rates of hospitalization resulting from adverse drug reactions, adverse drug events and MRP s were 7% (interquartile range, 2.4–14.9%), 4.6% (interquartile range, 2.85–16.6%) and 12.1% (interquartile range, 6.43–22.2%), respectively. The major causes contributing to MRP s were adverse drug reactions and noncompliance. In addition, the major risk factors associated with MRP s were old age, polypharmacy and comorbidities. Moreover, the main classes of medicines implicated were medicines used to treat cardiovascular diseases and diabetes. Conclusions Hospitalization due to MRP s had a high prevalence, in the range of 4.6–12.1%. Most MRP s encountered were prevalent among adult patients taking medicines for cardiovascular diseases and diabetes.