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Indirect comparison analysis of efficacy and safety between olanzapine and aripiprazole for schizophrenia
Author(s) -
Kunitomi Taro,
Hashiguchi Masayuki,
Mochizuki Mayumi
Publication year - 2014
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/bcp.12221
Subject(s) - aripiprazole , olanzapine , placebo , risperidone , positive and negative syndrome scale , medicine , schizophrenia (object oriented programming) , psychology , psychiatry , psychosis , alternative medicine , pathology
Aims Indirect comparison ( IC ) and direct comparison ( DC ) between aripiprazole and olanzapine for schizophrenia were conducted to compare their efficacy and safety. The objective was to determine the usability of IC and consistency of results delivered by the two comparisons. Factors that might influence the inconsistency of results were also investigated. Methods IC s and DC s were conducted using the change from baseline of the P ositive and N egative S yndrome S cale ( PANSS ) total score as an efficacy endpoint and the dropout rate was selected as a safety endpoint. Placebo and risperidone were used as common comparators for IC s. Results A literature search identified 20 articles. The efficacy analysis gave results on the mean difference in PANSS change (95% CI ) of −5.72 (−10.22, −1.22) in IC s using placebo as a common comparator and −7.41 (−15.96, 1.14) in DC s. When using risperidone as a common comparator, it was −9.15 (−20.12, 1.82). In rate ratio analysis of the all cause dropout rate, the IC result was 1.17 (0.83, 1.65) using placebo as a common comparator and 1.56 (0.57, 4.26) using risperidone as a common comparator. Both analyses gave consistent results between IC s and DC s. A slightly lower estimated value was observed in IC s using placebo. Conclusions This study demonstrated that IC s between olanzapine and aripiprazole can deliver results consistent with those of DC s. It is also suggested that the selection of a common comparator is important when control group bias is suspected in the data set.