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Romiplostim dose–response in patients with myelodysplastic syndromes
Author(s) -
Perez Ruixo Juan Jose,
Doshi Sameer,
Wang YowMing C.,
Mould Diane R.
Publication year - 2013
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/bcp.12041
Subject(s) - romiplostim , pharmacodynamics , medicine , platelet , pharmacokinetics , myelodysplastic syndromes , bone marrow , thrombopoietin , pharmacology , haematopoiesis , stem cell , biology , genetics
Aim To characterize the romiplostim dose–response in subjects with low or intermediate‐1 risk myelodysplastic syndromes ( MDS ) receiving subcutaneous romiplostim. Methods Data from 44 MDS subjects receiving subcutaneous romiplostim (dose range 300–1500 μg week −1 ) were used to develop a pharmacodynamic model consisting of a romiplostim‐sensitive progenitor cell compartment linked to the peripheral blood compartment through four transit compartments representing the maturation in the bone marrow from megakaryocytes to platelets. A kinetics of drug effect model was used to quantify the stimulatory effect of romiplostim on the proliferation of sensitive progenitor cells and pharmacodynamics‐mediated disposition was modelled by assuming the kinetics of drug effect constant ( k DE ) to be proportional to the change in platelet count relative to baseline. Results The estimated values (between subject variability) for baseline platelet count, mean transit time, and k DE were 24 × 10 9 l −1 (47%), 9.6 days (44%) and 0.28 days −1 , respectively. MDS subjects had a shorter platelet lifespan (42 h) than healthy subjects (257 h). Romiplostim effect was described for responders (78%) and non‐responders (22%). The average weekly stimulatory effect of romiplostim on the production rate of sensitive progenitor cells at baseline was 269% per 100 μg week −1 for responders. Body weight, age, gender and race were not statistically related to romiplostim pharmacodynamic parameters. Visual predictive checks confirmed the model adequacy. Conclusion The time course of platelet counts in MDS subjects receiving subcutaneous administration of escalating doses of romiplostim was characterized and showed a linear dose–response for romiplostim responders to increase the platelet counts.