Premium
Antifungal agents and therapy for infants and children with invasive fungal infections: a pharmacological perspective
Author(s) -
Lestner Jodi M.,
Smith P. Brian,
CohenWolkowiez Michael,
Benjamin Daniel K.,
Hope William W.
Publication year - 2013
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/bcp.12025
Subject(s) - antifungal , intensive care medicine , antifungal drugs , medicine , pharmacodynamics , perspective (graphical) , pharmacokinetics , pharmacology , dermatology , computer science , artificial intelligence
Invasive fungal infections, although relatively rare, are life‐threatening diseases in premature infants and immunocompromised children. While many advances have been made in antifungal therapeutics in the last two decades, knowledge of the pharmacokinetics and pharmacodynamics of antifungal agents for infants and children remains incomplete. This review summarizes the pharmacology and clinical utility of currently available antifungal agents and discusses the opportunities and challenges for future research.