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Severe metabolic acidosis due to acetazolamide intoxication in a dog
Author(s) -
Johnston L,
Leister E,
Singer L
Publication year - 2020
Publication title -
australian veterinary journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.382
H-Index - 59
eISSN - 1751-0813
pISSN - 0005-0423
DOI - 10.1111/avj.13027
Subject(s) - acetazolamide , metabolic acidosis , carbonic anhydrase inhibitor , acidosis , sodium bicarbonate , medicine , anesthesia , bicarbonate , case presentation , carbonic anhydrase , presentation (obstetrics) , physiology , surgery , biology , chemistry , biochemistry , enzyme
Case report This case report describes the clinical signs and case management of a 1‐year‐old neutered male Siberian Husky that accidentally ingested 635 mg/kg of oral acetazolamide (a carbonic anhydrase inhibitor). The dog presented with severe tachypnoea due to the development of hyperchloraemic metabolic acidosis and associated hypokalaemia that persisted for 7 days. Clinical and biochemical changes resolved with intravenous and subsequent oral supplementation of sodium bicarbonate and potassium. Complete recovery occurred within 9 days of presentation. Conclusion To the authors' knowledge, this is the first case that reports overdosage of an oral carbonic anhydrase inhibitor in a dog and subsequent recovery with adequate supplementation and supportive care.