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Long‐term control of olfactory neuroblastoma in a dog treated with surgery and radiation therapy
Author(s) -
Gumpel E,
Moore AS,
Simpson DJ,
Hoffmann KL,
Taylor DP
Publication year - 2017
Publication title -
australian veterinary journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.382
H-Index - 59
eISSN - 1751-0813
pISSN - 0005-0423
DOI - 10.1111/avj.12602
Subject(s) - cribriform plate , medicine , nasal cavity , radiation therapy , esthesioneuroblastoma , surgery , neuroblastoma , malignancy , surgical excision , pathology , biology , genetics , cell culture
Background Olfactory neuroblastoma is a rare malignancy of the nasal cavity in dogs that is thought to arise from specialised sensory neuroendocrine olfactory cells derived from the neural crest. Case report An 8‐year‐old dog was presented for reclusiveness and pacing. On CT and MRI , a contract‐enhancing mass was disclosed within the rostral fossa, extending caudally from the cribriform plate into the left nasal sinus. Surgical excision was performed and the diagnosis was histological grade III (Hyams grading scheme) olfactory neuroblastoma. Based on human CT criteria this was high stage (modified Kadish stage C). Surgical excision was incomplete and was followed by curative‐intent radiation therapy using a linear accelerator to a total dose of 48 Gy. Conclusion The dog survived 20 months after diagnosis. Although olfactory neuroblastoma is a rare tumour in dogs, aggressive local therapy may allow for prolonged survival, even when the tumour is advanced.