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Hypocobalaminaemia as a cause of bone marrow failure and pancytopenia in a cat
Author(s) -
Stanley EL,
Eatroff AE
Publication year - 2017
Publication title -
australian veterinary journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.382
H-Index - 59
eISSN - 1751-0813
pISSN - 0005-0423
DOI - 10.1111/avj.12570
Subject(s) - pancytopenia , macrocytosis , medicine , lethargy , anisocytosis , neutropenia , bone marrow , bone marrow examination , anemia , leukopenia , cobalamin , bone marrow failure , pathology , gastroenterology , vitamin b12 , chemotherapy , haematopoiesis , biology , genetics , stem cell
Case report A male Domestic Short‐hair cat was presented for chronic weight loss, lethargy and hyporexia. Complete haematological examination revealed non‐regenerative anaemia, neutropenia and thrombocytopenia, as well as Howell‐Jolly bodies, anisocytosis, polychromasia and macrocytosis on blood smear evaluation. Histopathological evaluation of bone marrow biopsy disclosed hypocellularity consistent with bone marrow failure. Concurrent hypocobalaminaemia was identified and treated with parenteral cyanocobalamin supplementation. Other differential diagnoses for pancytopenia, including infectious, toxic, immune‐mediated and neoplastic causes, were ruled out. Conclusion The cat's erythrocyte, leucocyte and platelet counts normalised after 2 months of cyanocobalamin supplementation, suggesting that pancytopenia may be a rare manifestation of feline cobalamin deficiency.