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Glucocorticoid‐deficient hypoadrenocorticism secondary to intravascular lymphoma in the adrenal glands of a dog
Author(s) -
Buckley ME,
Chapman PS,
Walsh A
Publication year - 2017
Publication title -
australian veterinary journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.382
H-Index - 59
eISSN - 1751-0813
pISSN - 0005-0423
DOI - 10.1111/avj.12539
Subject(s) - zona glomerulosa , zona fasciculata , medicine , lymphoma , glucocorticoid , zona reticularis , endocrinology , population , pathology , adrenal gland , blood pressure , environmental health , angiotensin ii
Case report A 2‐year‐old neutered male German Shepherd dog was presented with weakness, poor appetite and weight loss. Glucocorticoid‐deficient hypoadrenocorticism was diagnosed with undetectable pre‐ and post‐ ACTH cortisol concentrations but normal sodium and potassium concentrations. Despite appropriate supplementation with glucocorticoids, the patient's weakness progressed and neurological deficits developed. The patient was euthanased. Histopathological analysis of multiple organs, including the adrenal glands, showed an accumulation of neoplastic lymphocytes within blood vessels, consistent with a diagnosis of intravascular lymphoma. Histologically, in both adrenal glands, the architecture of the zona fasciculata and reticularis was disrupted by blood vessels congested with a neoplastic population of T‐lymphocytes; the zona glomerulosa remained intact. Conclusion This is the first report of intravascular lymphoma causing glucocorticoid‐deficient hypoadrenocorticism in a dog.