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Genome‐wide association studies reveal additional related loci for fatty acid composition in a Duroc pig multigenerational population
Author(s) -
Sato Shuji,
Uemoto Yoshinobu,
Kikuchi Takashi,
Egawa Sachiko,
Kohira Kimiko,
Saito Tomomi,
Sakuma Hironori,
Miyashita Satoshi,
Arata Shinji,
Suzuki Keiichi
Publication year - 2017
Publication title -
animal science journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.606
H-Index - 38
eISSN - 1740-0929
pISSN - 1344-3941
DOI - 10.1111/asj.12793
Subject(s) - single nucleotide polymorphism , intramuscular fat , biology , genome wide association study , candidate gene , quantitative trait locus , genetics , snp , fatty acid , population , genetic association , gene , genotype , biochemistry , medicine , environmental health
The aim of the present study was to detect quantitative trait loci affecting fatty acid composition in back fat and intramuscular fat in a Duroc pig population comprising seventh‐generation pedigrees using genome‐wide association studies ( GWAS ). In total, 305 animals were genotyped using single nucleotide polymorphisms ( SNP s) array and five selected SNPs from regions containing known candidate genes related to fatty acid synthesis or metabolism. In total, 24 genome‐wide significant SNP regions were detected in 12 traits, and 76 genome‐wide suggestive SNP regions were detected in 33 traits. The Sus scrofa chromosome ( SSC ) 7 at 10.3 Mb was significantly associated with C17:0 in intramuscular fat, while the SSC 9 at 13.6 Mb was significantly associated with C14:0 in intramuscular fat. The SSC 12 at 1.0 Mb was significantly associated with C14:0 in back fat and the SSC 14 at 121.0 Mb was significantly associated with C18:0 in intramuscular fat. These regions not only replicated previously reported loci containing some candidate genes involved in fatty acid composition ( fatty acid synthase and stearoyl‐CoA desaturase ) but also included several additional related loci.