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Effects of fatty acid transport protein 1 on proliferation and differentiation of porcine intramuscular preadipocytes
Author(s) -
Chen Xiaoling,
Luo Yanliu,
Wang Ruisheng,
Zhou Bo,
Huang Zhiqing,
Jia Gang,
Zhao Hua,
Liu Guangmang
Publication year - 2017
Publication title -
animal science journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.606
H-Index - 38
eISSN - 1740-0929
pISSN - 1344-3941
DOI - 10.1111/asj.12701
Subject(s) - adipogenesis , intramuscular fat , chemistry , medicine , endocrinology , fatty acid binding protein , adipose tissue , perilipin , wnt signaling pathway , downregulation and upregulation , fatty acid , microbiology and biotechnology , biology , signal transduction , biochemistry , adipocyte , gene
Fatty acid transport protein 1 (FATP1) plays an important role in the fatty acid transmembrane transport and fat deposition. However, its role in porcine intramuscular preadipocytes proliferation and differentiation remain poorly understood. Here, we examined the effects of pFATP1 on porcine intramuscular preadipocytes proliferation and differentiation. Overexpression of pFATP1 in porcine intramuscular preadipocytes significantly promoted the proliferation of porcine intramuscular preadipocytes, and also significantly upregulated the expressions of peroxisome proliferator‐activated receptor γ, CCAAT enhancer binding protein α, lipoprotein lipase, fatty acid synthetase and perilipin 1. Moreover, overexpression of pFATP1 in porcine intramuscular preadipocytes significantly increased fat accumulation and downregulated β‐catenin protein expression. Overall, our results indicated that pFATP1 played an important role in porcine intramuscular preadipocytes proliferation and differentiation, and it might promote adipogenesis in porcine intramuscular preadipocytes by repressing Wnt/β‐catenin signaling pathway.