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Long‐term impact of puerperal metritis on the profiles of peripheral blood leukocytes in peripartum dairy cows
Author(s) -
Magata Fumie,
Kitaoka Ryuji,
Morino Ikumi,
Teramura Makoto,
Kawashima Chiho,
Haneda Shingo,
Shimizu Takashi
Publication year - 2016
Publication title -
animal science journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.606
H-Index - 38
eISSN - 1740-0929
pISSN - 1344-3941
DOI - 10.1111/asj.12516
Subject(s) - metritis , medicine , endometritis , immune system , lymphocyte , inflammation , peripheral blood , monocyte , cd8 , physiology , immunology , pregnancy , lactation , biology , ice calving , genetics
To determine the effects of puerperal metritis on the immune response, changes in the differential peripheral blood leukocyte counts were analyzed during the peripartum period in cows with or without metritis. Multiparous Holstein cows were examined for uterine health disorders and classified into two groups: healthy ( n = 11) or metritis ( n = 5) cows. The lymphocyte and monocyte counts and the proportion of CD8 + lymphocytes were higher in cows with metritis compared to healthy cows. Moreover, the effects of puerperal metritis on the lymphocyte counts and CD4 + /CD8 + ratio persisted weeks after the uterine inflammation had self‐resolved. Taken together, the findings of the present study indicate the possible long‐term alterations of systemic immune responses in cows with puerperal uterine inflammation. © 2015 Japanese Society of Animal Science