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Immunogenic properties and mycoplasmal pneumonia of swine (MPS) lung lesions in Large White pigs selected for higher peripheral blood immune capacity
Author(s) -
Borjigin Liushiqi,
Shimazu Tomoyuki,
Katayama Yuki,
Li Meihua,
Satoh Takumi,
Watanabe Kouichi,
Kitazawa Haruki,
Roh Sanggun,
Aso Hisashi,
Katoh Kazuo,
Uchida Takafumi,
Suda Yoshihito,
Sakuma Akiko,
Nakajo Mituru,
Suzuki Keiichi
Publication year - 2016
Publication title -
animal science journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.606
H-Index - 38
eISSN - 1740-0929
pISSN - 1344-3941
DOI - 10.1111/asj.12471
Subject(s) - immunity , immune system , biology , cellular immunity , immunology , lung , cd8 , mycoplasma hyopneumoniae , medicine , virology
Immunogenic properties and mycoplasmal pneumonia of swine (MPS) lung lesions were compared between the immunity‐selected Large White line and the non‐selected Large White line. The selected Large White line showed a higher level of pulmonary MPS lesions compared with the non‐selected Large White line. Subsequent to vaccination, the percentage of natural killer cells and T cells (CD3 + CD4 + CD8 ‐ and CD3 + CD4 − CD8 + T cells) were significantly increased in the non‐selected line but remained unchanged in the immunity‐selected Large White line. Secretion of Mycoplasma hyopneumoniae vaccine‐specific immunoblogulin G and phagocyte activity in peripheral blood were significantly higher in the immunity‐selected Large White line than in the non‐selected line. Expression of interleukin (IL)‐4 and IL‐6 messenger RNA in hilar lymph nodes was significantly lower in the immunity‐selected Large White line than in the non‐selected line. However, expression of IL‐10 in all immune tissues was significantly higher in the immunity‐selected Large White line. These results suggest that the selection for high immunity was not effective in increasing resistance to MPS lung lesions.