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Immunogenic properties of Landrace pigs selected for resistance to mycoplasma pneumonia of swine
Author(s) -
Borjigin Liushiqi,
Shimazu Tomoyuki,
Katayama Yuki,
Li Meihua,
Satoh Takumi,
Watanabe Kouichi,
Kitazawa Haruki,
Roh Sanggun,
Aso Hisashi,
Katoh Kazuo,
Uchida Takafumi,
Suda Yoshihito,
Sakuma Akiko,
Nakajo Mituru,
Suzuki Keiichi
Publication year - 2016
Publication title -
animal science journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.606
H-Index - 38
eISSN - 1740-0929
pISSN - 1344-3941
DOI - 10.1111/asj.12440
Subject(s) - mycoplasma hyopneumoniae , tlr2 , vaccination , tlr4 , peripheral blood mononuclear cell , immunology , biology , immune system , immunity , medicine , microbiology and biotechnology , biochemistry , in vitro
Mycoplasma pneumonia of swine (MPS) lung lesions and immunogenic properties were compared between a Landrace line that was genetically selected for reduced incidence of pulmonary MPS lesions, and a non‐selected Landrace line. The MPS‐selected Landrace line showed significantly lower degrees of pulmonary MPS lesions compared with the non‐selected Landrace line. When changes in immunity before and after vaccination were compared, the percentage of B cells in the peripheral blood of the MPS‐selected Landrace line was significantly lower than that of the non‐selected line. Furthermore, the concentration of growth hormone and the mitogen activity of peripheral blood mononuclear cells in the MPS‐selected Landrace line showed significantly ( P < 0.05) lower increases after vaccination than the non‐selected line. Conversely, the concentration of peripheral blood interferon (IFN)‐γ and salivary immunoglobulin A (IgA) after Mycoplasma hyopneumoniae vaccination was significantly higher in the MPS‐selected Landrace line than in the non‐selected line. Gene expression of toll‐like receptor (TLR)2 and TLR4 was significantly higher in the MPS‐selected Landrace line in immune tissues, with the exception of the hilar lymph nodes. The present results suggest that peripheral blood IFN‐γ, salivary IgA TLR2, and TLR4 are important immunological factors influencing the development of MPS lesions.