Premium
Genetic selection for resistance to mycoplasmal pneumonia of swine ( MPS ) in the L andrace line influences the expression of soluble factors in blood after MPS vaccine sensitization
Author(s) -
Shimazu Tomoyuki,
Borjigin Liushiqi,
Katayama Yuki,
Li Meihua,
Satoh Takumi,
Watanabe Kouichi,
Kitazawa Haruki,
Roh Sanggun,
Aso Hisashi,
Kazuo Katoh,
Suda Yoshihito,
Sakuma Akiko,
Nakajo Mituru,
Suzuki Keiichi
Publication year - 2014
Publication title -
animal science journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.606
H-Index - 38
eISSN - 1740-0929
pISSN - 1344-3941
DOI - 10.1111/asj.12158
Subject(s) - mycoplasma hyopneumoniae , biology , immunology , vaccination , population , hormone , antibody , virology , medicine , endocrinology , environmental health
We recently developed a L andrace line that is resistant to mycoplasmal pneumonia of swine ( MPS ) infection by genetic selection for five generations, and we reported that the immunophenotype of this line is different from that of the non‐selected line in terms of changes in peripheral blood leukocyte population after MPS vaccination. This study followed up previous findings demonstrating changes in soluble factors in blood, namely, hormones, M ycoplasma hyopneumoniae ‐specific immunoglobulin G ( IgG ), and cytokines. These two lines were injected with MPS vaccine on days −7 and 0 after blood sampling on those days, and blood samples were collected on days −14, −7, 0, 2, 7 and 14. We found changes in the levels of many hormones and cytokines in both lines. However, we found that only growth hormone ( GH ) and interferon ( IFN )‐γ levels were statistically different between these two lines. GH concentration was reduced (day 0) and IFN ‐γ concentration was increased (day 14) in the MPS ‐selected line compared with the non‐selected line, despite unchanged IFN ‐γ messenger RNA expression in blood cells. Although detailed mechanisms underlying these phenotypes remain unsolved, these traits would be useful to improve MPS resistance in pig production and provide an insight into MPS infection.