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Genome‐wide association study for fatty acid composition in J apanese B lack cattle
Author(s) -
Ishii Atsushi,
Yamaji Keita,
Uemoto Yoshinobu,
Sasago Nanae,
Kobayashi Eiji,
Kobayashi Naohiko,
Matsuhashi Tamako,
Maruyama Shin,
Matsumoto Hirokazu,
Sasazaki Shinji,
Mannen Hideyuki
Publication year - 2013
Publication title -
animal science journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.606
H-Index - 38
eISSN - 1740-0929
pISSN - 1344-3941
DOI - 10.1111/asj.12063
Subject(s) - single nucleotide polymorphism , snp , fatty acid synthase , biology , fatty acid , genetics , candidate gene , genotype , gene , genetic association , genome wide association study , polymorphism (computer science) , biochemistry
Fatty acid composition is one of the important traits in beef. The aim of this study was to identify candidate genomic regions for fatty acid composition by genome‐wide association study with 50 K single nucleotide polymorphism ( SNP ) array in J apanese B lack cattle. A total of 461 individuals and 40 657 SNPs were used in this study. We applied genome‐wide rapid association using mixed model and regression ( GRAMMAR ) and genomic control approaches to estimate the associations between genotypes and fatty acid composition. In addition, two SNPs in fatty acid synthase ( FASN ) ( T1952A ) and stearoyl‐ CoA desaturase ( SCD ) ( V293A ) genes were also genotyped. Association analysis revealed that 30 significant SNPs for several fatty acids ( C 14:0, C 14:1, C 16:1 and C 18:1) were located in the BTA19 FASN gene located within this region but the FASN mutation had no significant effect on any traits. We also detected one significant SNP for C 18:1 on BTA23 and two SNPs for C 16:0 on BTA25 . The region around 17 Mb on BTA26 harbored two significant SNPs for C 14:1 and SNP in SCD in this region showed the strongest association with C 14:1. This study demonstrated novel candidate regions in BTA19 , 23 and 25 for fatty acid composition.