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Laparoscopic surgery for familial multiple gastrointestinal stromal tumors with germ line c‐kit gene mutation
Author(s) -
Hashimoto Masahiro,
Takahashi Tsuyoshi,
Nakajima Kiyokazu,
Kurokawa Yukinori,
Miyazaki Yasuhiro,
Tanaka Koji,
Makino Tomoki,
Yamasaki Makoto,
Eguchi Hidetoshi,
Mori Masaki,
Doki Yuichiro
Publication year - 2021
Publication title -
asian journal of endoscopic surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.372
H-Index - 18
eISSN - 1758-5910
pISSN - 1758-5902
DOI - 10.1111/ases.12837
Subject(s) - gist , medicine , exon , germline mutation , stromal tumor , germline , mutation , stomach , stromal cell , laparoscopic surgery , pathology , surgery , gene , laparoscopy , genetics , biology
Familial gastrointestinal stromal tumor (GIST) is an exceedingly rare disease characterized by mutations in the c‐kit and platelet‐derived growth factor receptor alpha genes. We report the case of a 73‐year‐old woman with multiple submucosal tumors (SMTs) in the stomach and small intestine. Her elder sister had previously presented with multiple SMTs on examination and underwent surgery to remove the tumors because they showed a tendency to increase in size during follow‐up. The sister's tumors were pathologically diagnosed as GISTs, and a germ line mutation was recognized in exon 17 of c‐kit . Subsequently, the patient presented with multiple SMTs and the same germ line mutation as her sister. After 9 years of follow‐up, a single tumor was found to have grown in size, and SILS was performed for this SMT, which was also pathologically diagnosed as a GIST. To our knowledge, this is the first report of laparoscopic surgery for a case of familial GIST.