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Thoracoscopic right middle lobectomy for Mycobacterium abscessus in a young patient suspected of having congenital immunodeficiency
Author(s) -
Sekihara Keigo,
Hirai Hoshie,
Sumiya Ryusuke,
Momose Naoya,
Sugimura Aya,
Nagasaka Satoshi
Publication year - 2021
Publication title -
asian journal of endoscopic surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.372
H-Index - 18
eISSN - 1758-5910
pISSN - 1758-5902
DOI - 10.1111/ases.12828
Subject(s) - medicine , mycobacterium abscessus , immunodeficiency , clarithromycin , surgery , sputum , sinusitis , medical history , tuberculosis , mycobacterium , pathology , immunology , immune system , helicobacter pylori
Abstract Mycobacterium abscessus ( M. abscessus ) infection is resistant to multi‐antibacterial treatment, and surgical resection is often recommended. We report a case of M. abscessus infection in a young patient suspected of having a GATA2 mutation. A 19‐year‐old woman with a medical history of severe sinusitis and a family history of non‐tuberculous mycobacteriosis presented at our hospital. M. abscessus was confirmed by sputum culture. The patient received multidrug therapy, including clarithromycin. CT scan demonstrated bronchodilation and capacity decrease due to non‐obstructive atelectasis in the middle lobe. We performed thoracoscopic resection without complications. Congenital immunodeficiency was suspected given the patient's past medical and family history. The result of lymphocyte subset analysis revealed a GATA2 mutation, but no genetic mutation was detected by a next‐generation sequencer. The patient followed a good clinical course. This paper reports the successful treatment of an M. abscessus infection and the importance of checking the genetic background of young patients.