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Comparison of the invasiveness of conventional discectomy and microendoscopic discectomy for lumbar disc herniation: Differences in the methods of approach
Author(s) -
Hara Manabu,
Takahashi Hiroshi,
Yokoyama Yuichirou,
Wada Akihito,
Hasegawa Keiji,
Iida Yasuaki
Publication year - 2015
Publication title -
asian journal of endoscopic surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.372
H-Index - 18
eISSN - 1758-5910
pISSN - 1758-5902
DOI - 10.1111/ases.12143
Subject(s) - medicine , discectomy , creatine kinase , diskectomy , surgery , h&e stain , lumbar vertebrae , pathology , immunohistochemistry , lumbar
The aim of this study was to investigate whether differences in the methods of approach to the vertebral arch influence the invasiveness of conventional discectomy and microendoscopic discectomy ( MED ). Methods In this study, 41 Wistar rats were divided into four groups: controls (no surgery) ( n = 10), shams (skin incision only) ( n = 11), MED ( n = 10), and conventional discectomy ( n = 10). We performed ethological and blood biochemical examinations for three of the groups, excluding the control group, and a histological examination for three of the groups, excluding the sham group. In the ethological examination, we measured the threshold of postoperative pain using the von Frey test. In the blood chemical examination, we measured blood creatine phosphokinase and inflammatory cytokines, and compared the severity of tissue damage by histological examination using hematoxylin–eosin and immunohistochemical staining. Results The conventional discectomy group showed a significantly lower threshold of postoperative pain, compared with the MED group ( P < 0.05). Blood biochemical investigation revealed that the creatine phosphokinase ( P < 0.05) and tumor necrosis factor‐α levels ( P < 0.05) of the conventional discectomy group were significantly higher than those in the MED group. In the histological examination, it was found that a wide range of paraspinal muscle damage occurred in the conventional discectomy group ( P < 0.05) and that the damage was mostly confined to the periosteum and nearby nerve endings. Conclusion MED was found to be less invasive than conventional discectomy based on ethological, blood biochemical, and histological examinations.