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Detection of thyroid hormone receptors in the olfactory system and brain of wild masu salmon, Oncorhynchus masou (Brevoort), during smolting by in vitro autoradiography
Author(s) -
KUDO H.,
TSUNEYOSHI Y.,
NAGAE M.,
ADACHI S.,
YAMAUCHI K.,
UEDA H.,
KAWAMURA H.
Publication year - 1994
Publication title -
aquaculture research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.646
H-Index - 89
eISSN - 1365-2109
pISSN - 1355-557X
DOI - 10.1111/are.1994.25.s2.171
Subject(s) - olfactory epithelium , biology , thyroid , olfactory bulb , hormone , thyroid hormone receptor , endocrinology , medicine , receptor , cerebrum , olfactory receptor , olfactory system , epithelium , hormone receptor , central nervous system , neuroscience , biochemistry , genetics , cancer , breast cancer
Thyroid hormone regulates a number of physiological functions during smolting in salmonids. However, the target sites and roles of thyroid hormone in the central nervous system (CNS) are not known in detail. We detected thyroid hormone‐specific binding sites (i.e. thyroid hormone receptors) in the olfactory epithelium and the brain (the olfactory bulb, the telencephalon, the mid‐brain and the cerebellum) of wild masu salmon, Oncor- hynchus masou (Brevoort), during smolting by means of in vitro autoradiography with frozen sections. A saturation experiment with the brain indicated the presence of a single class of binding sites of high affinity. T3‐specific binding was detected in the olfactory epithelium and in all regions of the brain except the olfactory bulb. The T3‐specific binding value in the olfactory epithelium was higher than in all other regions of the brain. This binding value in the olfactory epithelium increased at the full‐smolt stage. The presence of thyroid hormone receptors in various regions of the CNS suggests that thyroid hormone plays an important role in the functional change in the brain and the olfactory epithelium during smolting.