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Effects of dietary astaxanthin on growth, blood biochemistry, antioxidant, immune and inflammatory response in lipopolysaccharide‐challenged Channa argus
Author(s) -
Zhu XinMing,
Li MuYang,
Liu XinYu,
Xia ChangGe,
Niu XiaoTian,
Wang GuiQin,
Zhang DongMing
Publication year - 2020
Publication title -
aquaculture research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.646
H-Index - 89
eISSN - 1365-2109
pISSN - 1355-557X
DOI - 10.1111/are.14550
Subject(s) - astaxanthin , biology , superoxide dismutase , glutathione peroxidase , malondialdehyde , endocrinology , medicine , lipopolysaccharide , alkaline phosphatase , antioxidant , feed conversion ratio , catalase , weight gain , oxidative stress , biochemistry , carotenoid , enzyme , body weight
The present study investigated the effects of dietary astaxanthin on the growth, blood biochemical, antioxidant, immune and inflammatory response in lipopolysaccharide‐challenged Channa argus . A total of 0, 50, 100 and 200 mg/kg of astaxanthin were added to the basal die for 56 days. After the feeding experiment, each group was subjected to a lipopolysaccharide challenge (except for the Control group). The results showed that adding astaxanthin to the diet can significantly increase the weight gain and specific growth rate and decrease the feed conversion ratio of C. argus ; the highest weight gain, specific growth rate and minimum feed conversion ratio occurred in the 100 mg/kg group. Furthermore, dietary astaxanthin supplementation can alleviate the negative effects of lipopolysaccharides by increasing the levels of alkaline phosphatase, lysozyme, complement 3, complement 4, total serum protein, albumin, globulin, superoxide dismutase, catalase and glutathione peroxidase and decrease the serum cortisol, aspartate aminotransferase, alanine aminotransferase, glutathione peroxidase, and malondialdehyde. Dietary astaxanthin supplementation also can decrease the relative expression of inflammatory genes (nuclear factor κB, interleukin‐1, interleukin‐8 and tumour necrosis factor‐α) in the liver, spleen, kidney and intestine. To summarise, dietary astaxanthin addition can improve the growth performance and attenuate the negative effects of lipopolysaccharide challenge in C. argus . The optimal amount of astaxanthin is 100 mg/kg.