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The effects of Coriandrum sativum L. as feed additive on mucosal immune parameters, antioxidant defence and, immune‐related genes expression in zebrafish ( Danio rerio )
Author(s) -
Safari Roghieh,
Hoseinifar Seyed Hossein,
Dadar Maryam,
Sattari Masoud,
Rahbar Mina
Publication year - 2019
Publication title -
aquaculture research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.646
H-Index - 89
eISSN - 1365-2109
pISSN - 1355-557X
DOI - 10.1111/are.14218
Subject(s) - coriandrum , biology , lysozyme , immune system , sativum , antioxidant , gene expression , zebrafish , gene , danio , andrology , food science , microbiology and biotechnology , immunology , biochemistry , botany , medicine
This study investigates the effects of Coriander ( C. sativum ) on the growth, antioxidant, and immune‐associated genes and serum and mucosal immune parameters in zebrafish ( D. rerio ). The experimental fish were treated with 0 [control], 5, 10 and 20 g/kg coriander supplemented diets for 8 weeks. The results revealed that coriander remarkably increased mucosal immune parameters (the total Immunoglobulin, protease and lysozyme activity). The highest levels of the measured parameters were noticed in 20 g/kg CP treatment. Also, the zebrafish fed 20 g/kg coriander powder showed significantly higher expression gene for lysozyme and TNF‐alpha . The same results were noticed in case of IL‐1B gene expression. In case of sod gene expression there was no significant difference between treatments. However, regarding cat gene expression, significant difference was noticed between 20 g/kg CP treatment and other groups. In addition, no significant changes were observed between coriander fed zebrafish and control treatments regarding GH gene expression level, although IGF‐I remarkable up‐regulate in 20 g/kg coriander powder treatment compared other groups. In conclusion, it can be proposed that dietary Coriander powder can improve mucosal immune parameters and immune and antioxidant genes expression.