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Effects of a dietary administration of purple coneflower ( Echinacea purpurea ) on growth, antioxidant activities and 8 mi RNA s expressions in crucian carp ( Carassius auratus )
Author(s) -
Tang XueLian,
Fu JingHua,
Li ZhiHua,
Fang WeiPing,
Yang JianYu,
Zou JiXing
Publication year - 2016
Publication title -
aquaculture research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.646
H-Index - 89
eISSN - 1365-2109
pISSN - 1355-557X
DOI - 10.1111/are.12624
Subject(s) - crucian carp , antioxidant , biology , superoxide dismutase , catalase , malondialdehyde , carassius auratus , glutathione peroxidase , grass carp , pharmacology , endocrinology , food science , biochemistry , fishery , fish <actinopterygii>
Echinacea purpurea ( EP ), a globally popular herbal medicine, has been used to treat various diseases in human and animals. However, little has been reported about its effects in fish. In this study, crucian carp ( Carassius auratus ) were selected to evaluate the effects of EP on growth performance and antioxidant response and the expressions of micro RNA s. The results showed EP could stimulate the growth of crucian carp with the best effect was observed at dose of 4 g kg −1 . In serum, the content of hydroxyl radical (· OH ) and malondialdehyde ( MDA ) decreased by EP supplementation, whereas the activities of superoxide dismutase ( SOD ), catalase ( CAT ) and glutathione reductase ( GR ) increased. Similarly, the content of · OH decreased, and the activities of CAT , GPX and GR increased in liver of crucian carp. Furthermore, in livers of crucian carp, EP supplements upregulated the expressions of the micro RNA s (miR‐16, miR‐21, miR‐125b, miR‐146a, miR‐155, miR‐181a and miR‐223), which had been confirmed to participate in regulating antioxidant and immune function in mammals. Our results suggest EP supplements in diets stimulated growth performance and antioxidant response of crucian carp. In liver, the upregulation of specific mi RNA s may participate in the antioxidant effects of EP diets.