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Prevalence of significant hepatic fibrosis using magnetic resonance elastography in a health check‐up clinic population
Author(s) -
Kang Kyung A,
Jun Dae Won,
Kim Mi Sung,
Kwon HeonJu,
Nguyen Mindie H.
Publication year - 2020
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/apt.15626
Subject(s) - medicine , fatty liver , magnetic resonance elastography , population , diabetes mellitus , cohort , fibrosis , hepatitis c , gastroenterology , hepatic fibrosis , liver disease , transient elastography , elastography , disease , liver fibrosis , environmental health , endocrinology , radiology , ultrasound
Summary Background Significant hepatic fibrosis is associated with higher mortality. However, data on the estimated prevalence of liver fibrosis in the general population are scarce. Aim To use magnetic resonance elastography (MRE) to investigate the prevalence of hepatic fibrosis in a Korean health check‐up clinic cohort. Methods We enrolled 2170 participants at our health check‐up clinic between January 2015 and May 2018, all of whom had MR with chemical shift technique and MRE. The primary objective was to estimate the prevalence of liver fibrosis. For generalisation, sex‐ and age‐standardised prevalence was calculated based on the Korean Statistical Information Service (KOSIS) during the period 2015‐2018. Results The prevalence of F2 (≥3.0 kPa) and F3 (≥3.6 kPa) in the overall cohort was 5.1% and 1.3% respectively (sex‐ and age‐adjusted prevalence of 3.8% and 1.3%). Non‐alcoholic fatty liver disease (NAFLD) prevalence (>5% fat fraction) was 27.7% in the average risk population (after excluding alcohol use and viral hepatitis), and the prevalence of significant and advanced fibrosis in NAFLD participants was 8.0% and 1.5% respectively. In participants with diabetes, 12.5% had ≥F2 and 4.3% ≥F3. In participants with NAFLD plus diabetes, 24.1% had ≥F2 and 6.0% ≥F3. On multivariate analysis, only age, insulin, diabetes and fatty liver on MR were independently associated with significant fibrosis. Conclusions In a Korean health check‐up clinic setting, the prevalence of significant and advanced liver fibrosis was 5.1% and 1.3% (sex‐ and age‐adjusted prevalence of 3.8% and 1.3%). The prevalence of advanced liver fibrosis was five times higher for diabetic participants with NAFLD.