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Association between chronic viral hepatitis and metabolic syndrome in southern Taiwan: a large population‐based study
Author(s) -
Kuo YuanHung,
Kee KwongMing,
Wang JingHoung,
Hsu NienTzu,
Hsiao ChangChun,
Chen Yi,
Lu ShengNan
Publication year - 2018
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/apt.14960
Subject(s) - medicine , metabolic syndrome , overweight , alanine transaminase , aspartate transaminase , body mass index , hepatitis c virus , hepatitis b virus , hepatitis b , hepatitis c , obesity , population , diabetes mellitus , gastroenterology , immunology , endocrinology , virus , environmental health , biochemistry , chemistry , alkaline phosphatase , enzyme
Summary Background The impact of metabolic syndrome (MetS) on hepatitis is an interesting issue. Aim To evaluate the association of MetS and chronic viral hepatitis including hepatitis B virus ( HBV ) and hepatitis C virus ( HCV ) infection in southern Taiwan. Methods From 2004 to 2013, a series of community‐based health screenings for residents aged 40 and older were held in Tainan city. MetS was defined according to the Joint Scientific Statement. Cut‐offs of body‐mass index measures of 24 kg/m 2 and 27 kg/m 2 were used to stratify lean, overweight and obese subjects. Results We enrolled 180 359 participants; the prevalence of MetS was 30.1%, which was significantly associated with advanced age and female sex. There were 18 726 (10.4%) HBV , 13 428 (7.4%) HCV , 1337 (0.7%) HBV plus HCV (B+C) and 146 868 (81.5%) non‐ HBV non‐ HCV participants ( NBNC ). Prevalence rates of MetS in subjects with HBV , HCV , B+C and NBNC were 25.2%, 31.5%, 28.9% and 30.7% respectively ( P < 0.001). There were 18.8% lean body, 35.4% overweight and 45.8% obese participants among 54 361 MetS subjects. Lean MetS subjects were older, had more diabetes, and had higher metabolic component levels, but lower alanine transaminase and aspartate transaminase‐platelet ratio index levels compared with obese MetS subjects. HCV infection was positively associated with MetS ( P < 0.001). However, HBV infection was inversely associated with MetS only among lean subjects ( P = 0.002), but not among the general population. Conclusions This large population‐based study indicated that HCV infection was positively associated with MetS. However, HBV infection was inversely associated with MetS only among lean subjects.