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Utility and cost evaluation of multiparametric magnetic resonance imaging for the assessment of non‐alcoholic fatty liver disease
Author(s) -
Eddowes P. J.,
McDonald N.,
Davies N.,
Semple S. I. K.,
Kendall T. J.,
Hodson J.,
Newsome P. N.,
Flintham R. B.,
Wesolowski R.,
Blake L.,
Duarte R. V.,
Kelly C. J.,
Herlihy A. H.,
Kelly M. D.,
Olliff S. P.,
Hübscher S. G.,
Fallowfield J. A.,
Hirschfield G. M.
Publication year - 2018
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/apt.14469
Subject(s) - medicine , transient elastography , fatty liver , steatosis , liver biopsy , gold standard (test) , magnetic resonance imaging , biopsy , population , fibrosis , gastroenterology , radiology , disease , environmental health
Summary Background Validated diagnostic tools that are accurate, cost effective and acceptable to patients are required for disease stratification and monitoring in NAFLD . Aims To investigate the performance and cost of multiparametric MRI alongside existing biomarkers in the assessment of NAFLD . Methods Adult patients undergoing standard of care liver biopsy for NAFLD were prospectively recruited at two UK liver centres and underwent multiparametric MRI , blood sampling and transient elastography withing 2 weeks of liver biopsy. Non‐invasive markers were compared to histology as the gold standard. Results Data were obtained in 50 patients and 6 healthy volunteers. Corrected T1 ( cT 1) correlated with NAFLD activity score (ρ = 0.514, P < .001). cT 1, enhanced liver fibrosis ( ELF ) test and liver stiffness differentiated patients with simple steatosis and NASH with AUROC (95% CI ) of 0.69 (0.50‐0.88), 0.87 (0.77‐0.79) and 0.82 (0.70‐0.94) respectively and healthy volunteers from patients with AUROC (95% CI ) of 0.93 (0.86‐1.00), 0.81 (0.69‐0.92) and 0.89 (0.77‐1.00) respectively. For the risk stratification of NAFLD , multiparametric MRI could save £150,218 per 1000 patients compared to biopsy. Multiparametric MRI did not discriminate between individual histological fibrosis stages in this population ( P = .068). Conclusions Multiparametric MRI accurately identified patients with steatosis, stratifies those with NASH or simple steatosis and reliably excludes clinically significant liver disease with superior negative predictive value (83.3%) to liver stiffness (42.9%) and ELF (57.1%). For the risk stratification of NAFLD , multiparametric MRI was cost effective and, combined with transient elastography, had the lowest cost per correct diagnosis.