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Systematic review: health‐related quality of life in children and adults with eosinophilic oesophagitis—instruments for measurement and determinant factors
Author(s) -
Lucendo A. J.,
AriasGonzález L.,
MolinaInfante J.,
Arias Á.
Publication year - 2017
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/apt.14194
Subject(s) - medicine , eosinophilic esophagitis , quality of life (healthcare) , disease , web of science , scopus , medline , health related quality of life , pediatrics , physical therapy , family medicine , meta analysis , nursing , political science , law
Summary Background Several measures have been used to assess the health‐related quality of life ( HRQ oL) of patients with eosinophilic oesophagitis (EoE). Aims To systematically review these HRQ oL measures, to appraise measurement properties of specific instruments and to evaluate determinant factors influencing HRQ oL in paediatric and adult EoE patients. Methods We searched the PubMed, Embase, Scopus, Web of Science (WOS) and Psyc INFO databases for documents providing original information on the development of measurement tools and/or evaluation of HRQ oL outcomes in EoE patients of all ages. Results Of the 596 references identified, data was collected from 34 studies (with only 16 of them being published as full papers) including a total of 1,689 individual patients. Three disease‐specific HRQ oL measures in EoE covering different aspects of patients’ lives and developed in English, were scored positive regarding measurement properties. The Peds QL inventory (including parent and child report forms) and the Peds‐QoL EoE module were the generic and specific instruments respectively used in children, while the SF ‐36 and EoE‐QoL‐A were the most used questionnaires in adults. Patients with EoE show an impaired HRQ oL compared to controls, which greatly depends on symptom severity and disease duration. Severity of endoscopic features and female gender may also determine an impaired HRQ oL. The effect of treatments on HRQ oL requires further assessment. Conclusions HRQ oL is a relevant outcome that should be considered in clinical practice and research of EoE. Further validation studies in several languages and populations are required to support the use of disease‐specific HRQ oL measures.