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Macrophage inhibitory cytokine‐1/growth differentiation factor‐15 as a predictor of colonic neoplasia
Author(s) -
Danta M.,
Barber D. A.,
Zhang H. P.,
LeeNg M.,
Baumgart S. W. L.,
Tsai V. W. W.,
Husaini Y.,
Saxena M.,
Marquis C. P.,
Errington W.,
Kerr S.,
Breit S. N.,
Brown D. A.
Publication year - 2017
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/apt.14156
Subject(s) - medicine , hyperplastic polyp , gastroenterology , gdf15 , adenoma , colonoscopy , colorectal cancer , carcinoma , colorectal adenoma , adenocarcinoma , cytokine , cancer , pathology
Summary Background Serum macrophage inhibitory cytokine‐1 ( MIC ‐1/ GDF 15) concentration has been associated with colonic adenomas and carcinoma. Aims To determine whether circulating MIC ‐1/ GDF 15 serum concentrations are higher in the presence of adenomas and whether the level decreases after excision. Methods Patients were recruited prospectively from a single centre and stratified into five groups: no polyps ( NP ); hyperplastic polyps ( HP ); sessile serrated ademona ( SSA ); adenomas ( AP ); and colorectal carcinoma ( CRC ). Blood samples were collected immediately before and 4 weeks after colonoscopy. MIC ‐1/ GDF 15 serum levels were quantified using ELISA . Results Participants (n=301) were stratified as: NP ; n=116 (52%), HP ; n=37 (12%), SSA ; n=19 (7%), AP ; n=68 (23%); and CRC ; n=3 (1%). Patients were excluded from the study due to nondiagnostic pathology (n=9, 3%) and exclusion criteria (n=20, 6%). In the 272 remaining subjects (M=149; F=123), age ( P =.005), history of colonic polyps ( P =.003) and family history of colonic polyps ( P =.002) were associated with presence of adenomas. Baseline median MIC ‐1/ GDF 15 serum levels increased significantly from NP 609 (460‐797) pg/ mL , HP 582 (466‐852) pg/ mL , SSA 561 (446‐837) pg/ mL to AP 723 (602‐1122) pg/ mL and CRC 1107 (897‐1107) pg/ mL ; ( P <.001). In the pre‐ and postpolypectomy paired adenoma samples median MIC ‐1/ GDF 15 reduced significantly from 722 (603‐1164) pg/ mL to 685 (561‐944) pg/ mL ( P =.002). A ROC analysis for serum MIC ‐1/ GDF 15 to identify adenomatous polyps indicated an area under the curve of 0.71. Conclusions Our data suggest that serum MIC ‐1/ GDF 15 has the diagnostic characteristics to increase the detection of colonic neoplasia and improve screening.