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Exposure to acid‐suppressing drugs during pregnancy and the risk of asthma in childhood: an observational cohort study
Author(s) -
Cea Soriano L.,
HernándezDíaz S.,
Johansson S.,
Nagy P.,
GarcíaRodríguez L. A.
Publication year - 2016
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/apt.13486
Subject(s) - medicine , asthma , hazard ratio , pregnancy , cohort , cohort study , pediatrics , incidence (geometry) , confidence interval , relative risk , confounding , observational study , proportional hazards model , obstetrics , genetics , physics , optics , biology
Summary Background Some research has suggested a potential link between prenatal exposure to proton pump inhibitors ( PPI s) or H 2 ‐receptor antagonists (H 2 RA s) and the development of childhood asthma. Aim To quantify the relative risk of asthma in children who experienced pre‐natal exposure to PPI s and/or H 2 RA s, adjusting for potential confounders. Methods In this observational cohort study ( NCT 01787435), women aged 18–45 years with completed pregnancies between January 1996 and December 2010 were identified from The Health Improvement Network in the United Kingdom, and were linked to infants. Hazard ratios ( HR s) were estimated using Cox proportional hazard models. Results Our analysis identified 2371 prenatally exposed and 7745 unexposed infants. The incidence of asthma (per 1000 person‐years) was 19.52 in the unexposed cohort, 23.88 in the PPI cohort and 32.16 in the H 2 RA cohort. After adjusting for maternal healthcare utilisation during the year before pregnancy, the HR for asthma in infants whose mothers received prescriptions at any time during pregnancy was 1.12 (95% confidence interval: 0.88–1.44) for PPI s and 1.43 (1.20–1.70) for H 2 RA s, when compared with unexposed infants. With further adjustment for maternal comorbidities and other medications, the HR for asthma was 1.03 (0.76–1.40) for PPI s and 1.32 (1.05–1.64) for H 2 RA s. Conclusions Our analysis showed no association between prenatal exposure to PPI s and asthma in childhood after adjusting for confounders. The association found for H 2 RA s may be explained largely by underlying environmental or genetic factors, as suggested by reductions in hazard ratio estimates following adjustment for maternal comorbidities.