Premium
Systematic review with meta‐analysis: endoscopic balloon dilatation for Crohn's disease strictures
Author(s) -
Morar P. S.,
Faiz O.,
Warusavitarne J.,
Brown S.,
Cohen R.,
Hind D.,
Abercrombie J.,
Ragunath K.,
Sanders D. S.,
Arnott I.,
Wilson G.,
Bloom S.,
Arebi N.
Publication year - 2015
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/apt.13388
Subject(s) - medicine , perforation , adverse effect , meta analysis , surgery , complication , anastomosis , balloon dilatation , crohn's disease , subgroup analysis , stenosis , balloon , disease , materials science , punching , metallurgy
Summary Background Endoscopic balloon dilatation ( EBD ) is recognised treatment for symptomatic Crohn's strictures. Several case series report its efficacy. A systematic analysis for overall efficacy can inform the design of future studies. Aim To examine symptomatic ( SR ) and technical response ( TR ) and adverse events ( AE ) of EBD . Stricture characteristics were also explored. Methods A systematic search strategy of COCHRANE , MEDLINE and EMBASE was performed. All original studies reporting outcomes of EBD for Crohn's strictures were included. SR was defined as obstructive symptom‐free outcome at the end of follow‐up, TR as post‐dilatation passage of the endoscope through a stricture, and adverse event as the presence of complication (perforation and/or bleeding). Pooled event rates across studies were expressed with summative statistics. Results Twenty‐five studies included 1089 patients and 2664 dilatations. Pooled event rates for SR , TR , complications and perforations were 70.2% (95% CI : 60–78.8%), 90.6% (95% CI : 87.8–92.8%), 6.4% (95% CI : 5.0–8.2) and 3% (95% CI : 2.2–4.0%) respectively. Cumulative surgery rate at 5 year follow‐up was 75%. Pooled unweighted TR , SR , complication, perforation and surgery rates were 84%, 45%, 15%, 9% and 21% for de novo and 84%, 58%, 22%, 5% and 32% for anastomotic strictures. Outcomes between two stricture types were no different on subgroup meta‐analysis. Conclusions Efficacy and complication rates for endoscopic balloon dilatation were higher than previously reported. From the few studies with 5 year follow‐up the majority required surgery. Future studies are needed to determine whether endoscopic balloon dilatation has significant long‐term benefits.