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Sleep and physical activity measured by accelerometry in Crohn's disease
Author(s) -
Langenberg D. R.,
Papandony M. C.,
Gibson P. R.
Publication year - 2015
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/apt.13160
Subject(s) - medicine , sleep (system call) , physical activity , physical therapy , actigraphy , gastroenterology , circadian rhythm , computer science , operating system
Summary Background Sleep and physical activity are inherent to human living, yet appear affected by Crohn's disease ( CD ), resulting in fatigue and disability. Aim To objectively assess sleep quality and physical activity and their associations using accelerometers, comparing CD vs. matched healthy control ( HC ) subjects. Methods Exactly 49 CD and 30 HC subjects completed surveys encompassing self‐reported fatigue and sleep quality, pathology testing and wore an accelerometer for 7 days, measuring physical activity and sleep. In this cross‐sectional observational study, per‐group comparisons were performed and in CD , factors associated with reduced activity and/or sleep quality were assessed via multivariate analyses. Results Regarding physical activity, CD subjects overall performed less total accelerometer counts (median 1.3 × 10 6 vs. 2.0 × 10 6 ), were more sedentary (97.7% vs. 96.2%) and completed fewer bouts of moderate‐vigorous intensity exercise (1.0 vs. 5.0, each P < 0.01 (Mann–Whitney) than HC over 7 days. Factors associated with poor physical activity in CD included elevated serum CRP ( OR = 22.6), lower vitamin D3 ( OR = 13.1) and longer disease duration ( OR = 1.2 per year, each P < 0.05). Regarding sleep, the CD group had similar total sleep time (median 458 vs. 447 min, P = 0.56), but more awakenings post‐sleep onset (22 vs. 11, P = 0.01). Factors associated with severe sleep dysfunction in CD included lower haemoglobin ( OR = 6.7) concurrent anti‐ TNF ( OR = 6.5, each P < 0.05) and opioid therapy (OR = 6.6, P = 0.09). Conclusion Utilising objective measurement in a habitual context over 7 days, patients with Crohn's disease exhibited poorer sleep quality and less physical activity than well‐matched healthy controls.