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The relationship between length of Barrett's oesophagus mucosa and body mass index
Author(s) -
Abdallah J.,
MaradeyRomero C.,
Lewis S.,
Perzynski A.,
Fass R.
Publication year - 2015
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/apt.12991
Subject(s) - medicine , body mass index , gastroenterology , odds ratio , obesity , correlation , logistic regression , population , mathematics , geometry , environmental health
Summary Background Length of Barrett's oesophagus ( BE ) is a risk factor for oesophageal cancer. The underlying mechanisms that determine BE length are nor fully known. Aim To determine if there is a correlation between obesity and length of BE . Methods Using a population‐based study, 381 patients diagnosed with Barrett's oesophagus between 1999 and 2013 were included. Body mass index ( BMI ) at the time of BE diagnosis was calculated. Upper endoscopy reports were reviewed to obtain the length of BE . Spearman's correlation coefficient was performed to assess the strength of the relationship between Barrett's length and BMI . A multivariate logistic regression analysis was conducted to further examine the association between BMI and length of BE . Results The adjusted odds ratio for each five‐point increase in BMI was 1.5 (95% CI 1.24–1.81, P < 0.001). The mean BMI was significantly higher in patients with long segment BE as compared to patients with short segment BE (32.7 vs. 30.3, P = 0.001). There was also a positive trend in long segment BE as patients entered into higher BMI categories (Z = 4.25, P < 0.001). There was a significant correlation between BMI and length of BE (r = 0.25, P < 0.0001). Conclusion The study demonstrated a correlation between BMI and the length of Barrett's oesophagus mucosa. Thus, increased BMI is associated with longer segment of Barrett's oesophagus.