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Review article: immunogenicity of anti‐TNF biologics in IBD – the role of patient, product and prescriber factors
Author(s) -
Moss A. C.,
Brinks V.,
Carpenter J. F.
Publication year - 2013
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/apt.12507
Subject(s) - medicine , adalimumab , immunogenicity , infliximab , concomitant , disease , inflammatory bowel disease , drug , intensive care medicine , clinical trial , observational study , immunology , antibody , pharmacology
Summary Background Anti‐drug antibodies ( ADA s) to biologic therapies contribute to the loss of response and infusion reactions to anti‐ TNF drugs in patients with inflammatory bowel disease ( IBD ). The reasons behind this immunogenicity are complex, and have not been the focus of a dedicated review for prescribers. Aim To provide an overview of the patient, product and prescriber factors, which have been associated with the immunogenicity of anti‐ TNF therapy, and draw conclusions for clinical practice. Methods Review of representative observational studies and clinical trials from the IBD and other literature, which report associations with ADA development, with a focus on infliximab and adalimumab. Results ADA s develop in 10–20% of patients receiving anti‐ TNF maintenance therapy, and these patients are three times more likely to lose response as ADA ‐negative patients. Patient genotype plays a role in ADA risk in a minority of patients, but age or disease type is not a major factor. Drug mishandling, such as agitation or freeze–thaw cycles, can induce protein aggregates, which are known to be immunogenic. Prescription of maintenance therapy with concomitant immunomodulators, and achieving suitable trough drug levels, reduces the risk of ADA s in patients with IBD . Conclusions Patients and prescribers can take several steps to reduce the risk of development of anti‐drug antibodies to anti‐ TNF antibodies. Further research is required to determine if immunogenic factors identified in other situations apply to use of anti‐ TNF s in IBD .