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Increased risk of herpes zoster among 108 604 patients with inflammatory bowel disease
Author(s) -
Long M. D.,
Martin C.,
Sandler R. S.,
Kappelman M. D.
Publication year - 2013
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/apt.12182
Subject(s) - medicine , inflammatory bowel disease , nested case control study , ulcerative colitis , cohort , retrospective cohort study , crohn's disease , cohort study , logistic regression , case control study , rate ratio , proportional hazards model , incidence (geometry) , risk factor , gastroenterology , disease , confidence interval , physics , optics
Summary Background Patients with inflammatory bowel disease ( IBD ) on certain immunosuppressants have increased herpes zoster ( HZ ) risk. Aim To determine the risk of HZ in IBD and how antitumour necrosis factor‐alpha (anti‐ TNF ) agents affect this risk. Methods We performed a retrospective cohort and nested case–control study using administrative data from IMS LifeLink ® Information Assets‐Health Plan Claims Database. In the cohort, we identified IBD patients