z-logo
Premium
Rifaximin treatment for the irritable bowel syndrome with a positive lactulose hydrogen breath test improves symptoms for at least 3 months
Author(s) -
Meyrat P.,
Safroneeva E.,
Schoepfer A. M.
Publication year - 2012
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/apt.12087
Subject(s) - rifaximin , flatulence , medicine , irritable bowel syndrome , bloating , lactulose , gastroenterology , abdominal pain , small intestinal bacterial overgrowth , hydrogen breath test , breath test , antibiotics , microbiology and biotechnology , biology , helicobacter pylori
Summary Background While rifaximin was able to improve symptoms in patients with irritable bowel syndrome ( IBS ) in phase III trials, these results are yet to be repeated in phase IV studies. Aim To evaluate the treatment response to rifaximin in IBS patients in a phase IV trial. Methods IBS patients underwent lactulose hydrogen breath testing ( LHBT ). LHBT ‐positive patients were treated with rifaximin for 14 days. Prior to treatment as well as at week 4 and 14 following the start of rifaximin treatment, patients completed a questionnaire assessing symptom severity on a Likert scale from 0 to 10. Results One hundred and six of 150 IBS patients (71%) were LHBT ‐positive and treated with rifaximin. As assessed at week 4 following commencement of the therapy, rifaximin provided significant improvement of the following IBS ‐associated symptoms: bloating (5.5±2.6 before the start of the treatment vs. 3.6±2.7 at week 4, P <0.001), flatulence (5.0±2.7 vs. 4.0±2.7, P =0.015), diarrhoea (2.9±2.4 vs. 2.0±2.4, P =0.005) and abdominal pain (4.8±2.7 vs. 3.3±2.5, P <0.001). Overall well‐being also significantly improved (3.9 ± 2.4 vs. 2.7 ± 2.3, P  < 0.001). Similar improvements in IBS symptoms were obtained at week 14. Eighty‐six per cent of patients undergoing repetitive LHBT (55/64) tested negative at week 4. Conclusions We found a high percentage of LHBT ‐positive IBS patients. IBS ‐associated symptoms (bloating, flatulence, diarrhoea, pain) were improved for a period of 3 months following 2 weeks of treatment with rifaximin. We conclude that rifaximin treatment alleviates symptoms in LHBT ‐positive IBS patients.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here