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Clinical characteristics of familial schizophrenia
Author(s) -
Liu Na,
Zhou Hui,
Xiong Xiangyu,
Li Qingwei,
Jiang Xuefeng,
Zhao Jingping,
Yang Xiaoxin,
Zhang Mingyuan,
Wang Xiangqun,
Wang Gang,
Yang Fude,
Hu Jian,
Zhang Xinjun,
Du Lingyang,
Li Huichun,
Feng Bing,
Hu Zhenyu,
Chen Zuoming,
Wang Chunxia,
Wang Xilin,
Zhang Jinbei,
Liu Tiebang,
Jia Fujun,
Sun Xueli,
Xu Xiufeng,
Meng Huaqing,
Wang Gaohua,
Zhang Ning,
Mei Qiyi,
Tan Qingrong,
Peng Chunqing,
Li Jing,
Lu Zheng
Publication year - 2021
Publication title -
asia‐pacific psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.654
H-Index - 21
eISSN - 1758-5872
pISSN - 1758-5864
DOI - 10.1111/appy.12422
Subject(s) - family history , schizophrenia (object oriented programming) , psychiatry , logistic regression , medicine , population , demographics , psychology , demography , environmental health , sociology
Abstract Introduction A family history of psychiatric disorders is one of the strongest risk factors for schizophrenia. The characteristics of patients with a family history of psychiatric disorders have not been systematically evaluated. Methods This multicenter study (26 centers, 2425 cases) was performed in a Chinese population to examine the sociodemographic and clinical characteristics of schizophrenia patients with a family history of psychotic disorders in comparison with those of patients with sporadic schizophrenia. Results Nineteen percent of patients had a family history of mental disease. Multiple logistic regression analysis revealed that ≥4 hospitalizations (OR = 1.78, P = .004), tobacco dependence (OR = 1.48, P = .006), alcohol dependence (OR = 1.74, P = .013), and physical illness (OR = 1.89, P = .001) were independently and significantly associated with a family history of mental disease. Conclusion Patients with a family history of mental disorders present different demographics and clinical features than patients without a family history of psychiatric disorders.