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Cognitive dysfunction in Malaysian patients with major depressive disorder: A subgroup analysis of a multicountry, cross‐sectional study
Author(s) -
Zainal Nor Zuraida,
Kalita Pranab,
Herr Keira Joann
Publication year - 2019
Publication title -
asia‐pacific psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.654
H-Index - 21
eISSN - 1758-5872
pISSN - 1758-5864
DOI - 10.1111/appy.12346
Subject(s) - major depressive disorder , depression (economics) , medicine , population , cross sectional study , cognition , subgroup analysis , marital status , psychiatry , psychology , physical therapy , meta analysis , economics , macroeconomics , environmental health , pathology
Cognitive dysfunction has been significantly associated with functional impairment in patients with major depressive disorder (MDD). Methods This is a subgroup analysis of 211 Malaysian patients recruited from the multicountry, multicenter, cross‐sectional Cognitive Dysfunction in Asian patients with Depression (CogDAD) study. Depression severity, cognitive dysfunction, and functional disability were assessed and compared with the overall CogDAD study population. Factors associated with functional disability were also evaluated in this Malaysian patient population. Results Approximately half of the Malaysian patients were in their first depressive episode, with the majority being treated for mild‐to‐moderate depression. Furthermore, Malaysian patients experienced cognitive dysfunction, with self‐reported Perceived Deficits Questionnaire (PDQ‐D) scores falling within the third quartile of PDQ‐D severity. Malaysian patients also reported functional disability evidenced by a mean total Sheehan Disability Scale (SDS) score of 11.47 ± 6.68, with the highest SDS score reported in the “Social Life/Leisure Activities” domain. Compared with the overall CogDAD study population, the Malaysian patient population had comparable patient demographics in terms of marital and working status; outcome scores for PHQ‐9 (9‐item Patient Health Questionnaire for self‐reported depression severity), PDQ‐D and SDS; and worst perceived cognitive dysfunction reported in the “Attention/Concentration” domain. Factors found to be significantly associated with functional disability were PDQ‐D score, sick leave taken, and antidepressant treatment ( P < 0.05). Discussion Findings from this subgroup analysis highlight the significance of treating cognitive dysfunction in patients with MDD and its correlation to functional disability.