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Maternal exposure to benzodiazepine and risk of preterm birth and low birth weight: A case‐control study using a claims database in Japan
Author(s) -
Ogawa Yusuke,
Takeshima Nozomi,
Furukawa Toshi A.
Publication year - 2018
Publication title -
asia‐pacific psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.654
H-Index - 21
eISSN - 1758-5872
pISSN - 1758-5864
DOI - 10.1111/appy.12309
Subject(s) - low birth weight , medicine , odds ratio , obstetrics , confidence interval , pregnancy , birth weight , premature birth , pediatrics , gestational age , genetics , biology
Purpose To examine (1) if the use of benzodiazepines and antidepressants during pregnancy may increase the risk of preterm birth and/or low birth weight (LBW), and, if yes, (2) which types of benzodiazepines or antidepressants have stronger influences. Methods A case‐control study was performed using a large claims database in Japan. Cases were mothers who had given birth to preterm and/or LBW infants between 2005 and 2014 (737 with preterm births and 1615 with LBW). Controls were mothers who had neither experienced preterm birth nor given birth to an LBW infant. Results Overall, 42 058 births were included. The maternal use of benzodiazepines was significantly associated with an increased risk of preterm birth (adjusted odds ratio [OR], 2.03; 95% confidence interval [CI], 1.11‐3.69, P < .05), while the maternal use of benzodiazepines was not significantly associated with LBW (adjusted OR, 1.55; 0.96‐2.50). The use of antidepressants was not significantly associated with both preterm deliveries (adjusted OR, 0.57; 0.08‐4.16) and LBW (adjusted OR, 0.56; 0.14‐2.29). Conclusions Benzodiazepine use was associated with increased risk of preterm birth but not with LBW. Antidepressant use was not associated with both preterm deliveries and LBW.