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Association of the 5‐HT 2A receptor gene promoter polymorphism‐1438G/A with anorexia nervosa and psychopathological traits in the Chinese Han population: A preliminary study
Author(s) -
Kang Qing,
Chen Jue,
Yu Shunying,
Yuan Aihua,
Zhang Yanxia,
Zhang Ran,
Jiang Wenhui,
Zhang Chen,
Zhang Haiyin,
Zhang Mingdao,
Xiao Zeping
Publication year - 2017
Publication title -
asia‐pacific psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.654
H-Index - 21
eISSN - 1758-5872
pISSN - 1758-5864
DOI - 10.1111/appy.12284
Subject(s) - psychopathology , transmission disequilibrium test , anorexia nervosa , polymorphism (computer science) , eating disorders , genotype , heterozygote advantage , population , medicine , genetics , psychology , biology , gene , single nucleotide polymorphism , psychiatry , environmental health
Abstract Objective The aim of the study was to explore the possible role of the 5‐HT 2A ‐1438G/A polymorphism in the susceptibility to anorexia nervosa (AN) in the Chinese Han population. Methods The ‐1438G/A polymorphism of 249 female AN patients, 228 matched healthy controls, and 198 trios was genotyped using SNaP shot assay. Psychopathological traits of eating‐disordered behaviors in AN subjects were examined using the Chinese version of the Eating Disorder Examination Questionnaire. Results Neither the case‐control analysis nor the transmission disequilibrium test revealed significant associations between the ‐1438G/A polymorphism and AN ( P > .05). However, AA homozygote patients with AN had lower weight and shape concern scores of the EDE‐Q6.0 than those of GA heterozygotes ( P < .05). Discussion Our findings suggested that female AN patients with 5‐HT 2A −1438AA genotype may be characterized by less severe eating‐disordered psychopathological traits in the Chinese Han population.