Early improvement predicts 8‐week treatment outcome in patients with generalized anxiety disorder treated with escitalopram or venlafaxine | Zendy

Qian Mincai | Zendy; Shen Zhongxia | Zendy; Lin Min | Zendy; Guan Tiefeng | Zendy; Yang Jianhong | Zendy; Li Liang | Zendy; Shen Xinhua | Zendy; Yuan Yonggui | Zendy

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Early improvement predicts 8‐week treatment outcome in patients with generalized anxiety disorder treated with escitalopram or venlafaxine

Author(s) -

Qian Mincai,

Shen Zhongxia,

Lin Min,

Guan Tiefeng,

Yang Jianhong,

Li Liang,

Shen Xinhua,

Yuan Yonggui

Publication year - 2017

Publication title -

asia‐pacific psychiatry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.654

H-Index - 21

eISSN - 1758-5872

pISSN - 1758-5864

DOI - 10.1111/appy.12270

Subject(s) - escitalopram , venlafaxine , generalized anxiety disorder , anxiety , rating scale , psychology , medicine , hamilton anxiety rating scale , psychiatry , antidepressant , developmental psychology

To investigate whether early improvement can predict 8‐week treatment outcome in generalized anxiety disorder (GAD) patients. Methods For 8 weeks, 226 GAD patients were randomly treated with escitalopram or venlafaxine. Early improvement was defined as a ≧20% reduction from baseline in Hamilton anxiety rating scale at week 1 or 2. The positive and negative predictive values were calculated. Results The positive and negative predictive values of early improvement in escitalopram or venlafaxine group at week 1 were (85.19%, 67.53%) vs (84.62%, 65.33%) Discussion The early improvement achieved within the first week treatment can predict a good 8‐week treatment outcome in GAD patients.

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