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Effectiveness of the repeated administration of scopolamine ointment on clozapine‐induced hypersalivation in patients with treatment‐resistant schizophrenia: A preliminary study
Author(s) -
Takeuchi Ippei,
Hanya Manako,
Uno Junji,
Fujita Kiyoshi,
Kamei Hiroyuki
Publication year - 2017
Publication title -
asia‐pacific psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.654
H-Index - 21
eISSN - 1758-5872
pISSN - 1758-5864
DOI - 10.1111/appy.12269
Subject(s) - hypersalivation , clozapine , anticholinergic , crossover study , placebo , glycopyrrolate , schizophrenia (object oriented programming) , medicine , anesthesia , scopolamine , parasympatholytic , psychology , pharmacology , psychiatry , muscarinic acetylcholine receptor , alternative medicine , atropine , pathology , receptor
Abstract Introduction This study investigated the efficacy of scopolamine (an anticholinergic agent) ointment against clozapine‐induced hypersalivation. Methods The patients enrolled in this study consisted of 10 clozapine‐treated schizophrenia patients and 10 healthy adult men. A prospective, randomized, double‐blind, crossover, placebo‐controlled clinical trial was designed. Results A total of 10 patients and 10 healthy adult men completed the study. No significant reduction in the saliva production of the clozapine‐treated patients was observed; however, that of the healthy adult men decreased significantly. Discussion Scopolamine ointment was not effective against clozapine‐induced hypersalivation. A further study is necessary for confirming its effect.