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Association of EPHB1 rs11918092 and EFNB2 rs9520087 with psychopathological symptoms of schizophrenia in Chinese Zhuang and Han populations
Author(s) -
Su Li,
Ling Weijun,
Jiang Juan,
Hu Jing,
Fan Jingyuan,
Guo Xiaojing,
Huang Guifeng,
Xie Xinfeng,
Long Jianxiong
Publication year - 2016
Publication title -
asia‐pacific psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.654
H-Index - 21
eISSN - 1758-5872
pISSN - 1758-5864
DOI - 10.1111/appy.12241
Subject(s) - single nucleotide polymorphism , psychopathology , snp , schizophrenia (object oriented programming) , positive and negative syndrome scale , association (psychology) , medicine , han chinese , clinical psychology , psychology , oncology , psychiatry , genetics , psychosis , biology , genotype , gene , psychotherapist
Two single‐nucleotide polymorphisms (SNPs) (rs11918092 and rs9520087) were genotyped in Chinese Zhuang and Han populations. Symptoms of schizophrenic patients were assessed by the Positive and Negative Syndrome Scale. No association of any SNP with schizophrenic susceptibility was found. However, associations of rs9520087 with the total scale score ( P = 0.014), positive scale score ( P = 0.013), negative scale score ( P = 0.032), and general psychopathology scale score ( P = 0.031) were found in Zhuang patients. Additionally, rs11918092 was associated with positive scale score ( P = 0.035) in Han patients. The two SNPs might influence symptoms of schizophrenia.